Study on the Mechanism of Electroacupuncture in the Treatment of Neuropathic Pain Based on Vesicular Glutamate Transporter 2/Toll Like Receptor 4 Signal Pathway

To explore the analgesic effect of electro-acupuncture on neuropathic pain model rats and to clarify mechanism analgesia from perspective vesicular glutamate transporter 2/toll like receptor 4 signal pathway. A total 30 specific pathogen free grade adult male Sprague-Dawley were selected. The randomly divided into group (chronic constriction injury), sham operation group, non-electro-acupuncture (sham electro-acupuncture), Chicago sky blue 6B lipopolysaccharide with 5 in each group. chronic injury sciatic nerve was established. “Huantiao” “Yanglingquan” points selected for electroacupuncture stimulation 14 d. mechanical foot contraction threshold, thermal pain, pathway protein levels inflammatory factor level compared analyzed. Compared thresholds decreased significantly (p<0.01), unilateral 2 toll release interalukin-6 spinal cord increased while interalukin-10 (p<0.01); intrathecal injection could increase threshold reduce interlukin-10; (p<0.01). Electro-acupuncture can alleviate sensitivity its occurrence development is closely related activation dorsal horn.